Digital color image processing and psychophysics within the framework of a human visual model

Journal ArticleA three-dimensional homomorphic model of human color vision based on neurophysiological and psychophysical evidence is presented. This model permits the quantitative definition of perceptually important parameters such as brightness. saturation, huo and strength. By modelling neural interaction in the human visual system as three linear filters operating on perceptual quantities, this model accounts for the automatic gain control properties of the eye and for brightness and color contrast effects. In relation to color contrast effects, a psychophysical experiment was performed. It utilized a high quality color television monitor driven by a general purpose digital computer. This experiment, based on the cancellation by human subjects of simultaneous color contrast illusions, allowed the measurement of the low spatial frequency part of the frequency responses of the filters operating on the two chromatic channels of the human visual system. The experiment is described and its results are discussed. Next, the model is shown to provide a suitable framework in which to perform digital images processing tasks. First, applications to color image enhancement are presented and discussed in relation to photographic masking techniques and to the handling of digital color images. Second, application of the model to the definition of a distortion measure between color images (in the sense of Shannon's rate-distortion theory), meaningful in terms of human evaluation, is shown. Mathematical norms in the "perceptual" space defined by the model are used to evaluate quantitatively the amount of subjective distortion present in artificially distorted color presented. Results of a coding experiment yielding digital color images coded at an average bit rate of 1 bit/pixel are shown. Finally conclusions are drawn about the implications of this research from the standpoints of psychophysics and of digital image processing

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Background: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods: For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings: Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14–2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low. Interpretation: Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons